Goal #3: Address health disparities 

Date: Sunday, April 14, 2024 &nbsp;Time: 12:00 p.m. - 4:00 p.m. ETLocation: Cleveland State University and Livestreaming/Virtual OptionRegistration: Only virtual registration is currently open&nbsp;There will be a livestreaming/virtual option for the Black Maternal Health Equity Summit hosted by the Clinical and Translational Science Collaborative (CTSC) of Northern Ohio. The summit will be hosted on Sunday, April 14 from 12 p.m. - 4 p.m. ET. &nbsp;&nbsp;Please register for the livestreaming/virtual attendance option before 11:59 p.m. ET on Friday, April 12 <a href="https://redcap.case.edu/surveys/?s=W87DF9AXA33AYCCP" target="_blank" rel="noopener noreferrer">here</a>.&nbsp;View the event details <a href="https://case.edu/medicine/ctsc/diversity-equity-inclusion-accessibility/black-maternal-health-equity-summit" target="_blank" rel="noopener noreferrer">here</a>.&nbsp;

Clinical and Translational Science Collaborative at Case Western Reserve University

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Case Western Reserve University

Virtual Option for Clinical and Translational Science Collaborative of Northern Ohio Black Maternal Health Equity Summit on Sunday, April 14

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Goal #1: Advance clinical and translational science

The CCOS Communications Team interviewed researchers at the <a href="https://ccos-cc.ctsa.io/groups/program-meetings/2023/fall-meeting?view=meeting-details" target="_blank" rel="noopener noreferrer">2023 CTSA Fall Program Annual Meeting</a> poster session in November as part of a series to feature ongoing projects across the CTSA hubs. In this article, we’re featuring Dr. Sarah Walker, TL1/32, Attending, and Advanced Research Fellow at Northwestern University who presented her work on a <a href="https://ccos-cc.ctsa.io/groups/program-meetings/2023/fall-meeting?view=poster-gallery&amp;poster=378" target="_blank" rel="noopener noreferrer">supervised machine learning model to predict fluid response in hypotensive children</a>.&nbsp;&nbsp;Research Question&nbsp;More than 600,000 children worldwide are diagnosed with shock, which has a mortality rate as high as 50% and causes one in three to experience long-term morbidities. The first step in shock resolution is the restoration of normal blood pressure through early and rapid fluid administration. However, fluid administration does not universally reverse low blood pressure in children, and both prolonged shock and excessive fluid administration contribute to morbidity and mortality. Hypotension in children is clinically difficult to manage, which inspired Dr. Walker and her team to use a machine learning-based model to predict which children would have a sustained positive clinical response to a fluid bolus to restore a normal blood pressure.&nbsp;&nbsp;Research Plan&nbsp;Dr. Walker plans to conduct a single-center retrospective study of critically ill children with low blood pressure who received at least 10 ml/kg of intravenous (IV) normal saline within 72 hours of pediatric intensive care unit admission between 2013 and 2023. Physiological variables will be extracted from data stored in bedside monitors and clinical variables will be extracted from electronic health records. Elastic net, random forest, and a long short-term memory model will be used to predict fluid responsiveness, which will be defined as an increase of at least 10% in the patient’s mean arterial pressure (MAP). Multiple organ dysfunction on day seven or death by day 28 will be compared between four groups: 1) Fluid Responsive (FR) and non-FRs, 2) predicted FRs and non-FRs, 3), FRs and non-FRs stratified by race/ethnicity, and 4) FRs and non-FRs stratified by sex as a biologic variable.&nbsp;&nbsp;Next Steps&nbsp;Dr. Walker and her team anticipate that approximately 800 critically ill children will receive 2,000 IV saline fluid boluses with a 60% rate of FR. The researchers hypothesize that non-FRs will have a higher complicated course than FRs. They also predict, based on previous adult studies, that patients of Black race and/or Hispanic ethnicity will have a higher rate of complicated course than those who are non-Hispanic and white, with no difference in complicated course when comparing biological sex.&nbsp;&nbsp;&nbsp;Reflection with the Researcher: What real-world benefits do you envision might come from work like this, and how would patients or community members benefit?&nbsp;&nbsp;&nbsp;Dr. Walker stated that “...in current practice, it is hard to determine which hypotensive children will improve after receiving IV fluids.” As such, Dr. Walker and her research team are also using machine learning to help predict which children might benefit from additional therapies, like targeted vasoactive medicines, in order to decrease overall hypotension-related morbidity and mortality in children.

Northwestern University Clinical and Translational Science Institute

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Northwestern University

2023 CTSA Fall Program Annual Meeting Poster Spotlight: Sarah Walker, M.D.

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Goal #7:  Training and career support programs for translational scientists

Date: Tuesday, April 23, 2024Time: 12:00 p.m. ETLocation: Zoom/VirtualPresentation: O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibros&nbsp;Shia Vang, Ph.D. candidate, Pre-Doctoral Scholar at the Center for Clinical and Translational Sciences, University of Alabama at Birmingham is presenting at the Yale Center for Clinical Investigation. Shia Vang will present on O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibros as part of the TL1 Schnaper Visiting Scientist Program. &nbsp;Join the presentation on Zoom <a href="https://yale.zoom.us/j/96486325003?pwd=NjRReG1pRGNaeXN3VEc0NGJFRGRZZz09" target="_blank" rel="noopener noreferrer">here</a>.

Yale Center for Clinical Investigation

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Yale University

Shia Vang, Ph.D. Candidate to Present as a Part of TL1 Schnaper Visiting Scientist Program Grand Rounds

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Virtual Option for Clinical and Translational Science Collaborative of Northern Ohio Black Maternal Health Equity Summit on Sunday, April 14