Surgical teams at NYU Langone Health performed the world’s first genetically modified pig kidney transplants into a human body in September and November 2021, and then transplanted two pig hearts in the summer of 2022. These procedures were done in patients declared dead based on neurologic criteria (decedents) and maintained on ventilators with the consent of their families. Demonstrating the field’s progress, NYU Langone in April 2024 transplanted a pig kidney into a living patient.
Now two new analyses, one published May 21 in Med and the other published online on May 17 in Nature Medicine, reveal changes at the single-cell level in the organs and recipients’ bodies before, during, and just after the xenotransplantation surgeries in decedents. Teams of scientists worked alongside the surgeons, taking blood and tissue samples to analyze changes in tens of thousands of collected cells…
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