Goal #1: Advance clinical and translational science

Novel uses of Geographic Information System (GIS) mapping programs can illuminate how multiple social and environmental determinants of health (SEDoH) drive disease and other health outcomes.&nbsp;&nbsp;Social and Environmental Determinants of Health (SEDoH) are of increasing interest to researchers in personal and public health. Collecting SEDoH and associating them with patient medical record can be challenging, especially for environmental variables. We announce here the release of SEnDAE, the Social and Environmental Determinants Address Enhancement toolkit, and open-source resource for ingesting a range of environmental variables and measurements from a variety of sources and associated them with arbitrary addresses…&nbsp;Read the full article <a href="https://www.sciencedirect.com/science/article/abs/pii/S0169260723002079?via%3Dihub" target="_blank" rel="noopener noreferrer">here</a>.

Southern California Clinical and Translational Science Institute

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University of Southern California

Southern California CTSI Researcher and Colleagues Create a Toolkit to Explore Associations Between Disease and Social and Environmental Factors

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N3C is pleased to announce that <a href="https://www.ariscience.com/" target="_blank" rel="noopener noreferrer">ARIScience</a>, an early user of N3C and also one of the finalists of the N3C-based COVID-19 AI pediatric challenge, has been awarded a research and development contract by the United States Biomedical Advanced Research Development Agency (BARDA) to discover candidate small molecules to counter respiratory depression by targeting two specific proteins. ARIScience continues to push its artificial intelligence combined with quantum chemistry-driven small molecule therapy discovery platform to target proteins that lie in disease pathways directly or allosterically across multiple disease conditions.&nbsp;&nbsp;

Colorado Clinical and Translational Sciences Institute

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University of Colorado Denver

Early N3C user, ARIScience, is awarded BARDA contract 

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Goal #4: Improve clinical research

A new paper from researchers at the Mayo Clinic reviews the effects of digital innovation on clinical trial participation and how new technologies applied beyond the clinic walls may overcome the limitations of conventional trials.&nbsp;&nbsp;Now, more than ever, digital technology has made its way into the daily lives of billions across the globe, and the widespread use of this technology has also allowed a digital window into consumers’ and patients’ daily lives, respectively. In a similar way, the practice of medicine has digitally evolved with the application of electronic health records and development of wearable/portable consumer-based medical devices (e.g., Apple Watch ECG and Kardia Mobile by AliveCor). Alongside the increased use of digital technology in clinical care (e.g., telehealth and wearable arrhythmia detection), clinical investigators have harnessed this powerful stockpile of data to gain insight into what happens to patients beyond the clinic walls. In this thematic review, we show the impact of digital advancements on the clinical trial process from recruitment and enrollment to interventions and data collection. We also show the pragmatism of this decentralized process and how it will mitigate the limitations of conventional randomized controlled trials. Finally, while pushing the boundaries of tech, we also describe a few limitations of this rapidly growing field to understand better what gaps need to be bridged in the future…&nbsp;Read the full article <a href="https://discoverysedge.mayo.edu/2023/05/15/participants-first-shaping-the-future-of-clinical-trials-through-digital-innovation/" target="_blank" rel="noopener noreferrer">here</a>.

Mayo Clinic Center for Clinical and Translational Science

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Mayo Clinic Rochester

Participants First: Shaping the Future of Clinical Trials Through Digital Innovation 

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Southern California CTSI Researcher and Colleagues Create a Toolkit to Explore Associations Between Disease and Social and Environmental Factors