Most chronic liver diseases follow a progression. Fatty deposits increase in liver tissue. These deposits cause repeated inflammation that the liver repairs while leaving scars. Such scarring, called fibrosis, blocks liver blood flow and can kill healthy cells and cause more scarring. People with HIV are especially vulnerable as chronic liver disease is a leading non-AIDS-related cause of their mortality.
Yet a subset of people with HIV and liver fibrosis—people with diabetes—have less fat in the liver but more scarring than non-diabetics, according to a prospective multicenter cohort study of 654 adults with HIV, recently published in the journal Hepatology…
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