Goal #4: Improve clinical research

Research coordinators are the critical link for recruitment and retention in clinical research. Tufts CTSI conducts twice-yearly trainings to teach clinical research staff practical skills of communicating informed consent. In these trainings, former research participants act as simulated patients to role play real world recruitment scenarios in a low-stakes context. Details on the evolution and effectiveness of this training and the role of community stakeholders can be found in the article “<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10260332/pdf/S2059866123005344a.pdf" target="_blank" rel="noopener noreferrer">Community Engaged Informed Consent Training</a>”*. Now Tufts CTSI is looking for collaborators to continue improving and expand the reach of this innovative program. For more information about how you can partner with Tufts CTSI on this program, email Kris Markman at <a href="mailto:training@tuftsctsi.org" target="_blank" rel="noopener noreferrer">training@tuftsctsi.org</a> and include “Informed Consent Training” in the subject line.&nbsp;&nbsp;*Markman KM, Weicker NP, Klein AK, Sege RS. Community engaged training in informed consent. Journal of Clinical and Translational Science. 2023:1-21. doi:10.1017/cts.2023.534

Tufts Clinical and Translational Science Institute

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Tufts University

Engaging Community Stakeholders in Clinical Research Staff Training

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Goal #2: Promote partnerships and collaborations

The newly constituted Southeast Wisconsin Data Science Collaborative, which includes the Medical College of Wisconsin (MCW) - Clinical and Translational Science Institute of Southeast Wisconsin (CTSI), together with several other CTSI of Southeast Wisconsin regional member institutions such as Marquette University (MU) and University of Wisconsin-Milwaukee (UW-M), in partnership with Northwestern Mutual Data Science Institute (NMDSI), hosted the first multi-campus Hack for Health event this Spring. &nbsp;&nbsp;The Hack for Health event, also known as a hackathon, is defined as a social event that brings computer programmers, data scientists and other professionals together, to improve upon and to build new software programs, applications, or new computational approaches to healthcare data. Twenty-three students from MCW, MU and UW-M worked competitively across seven teams, over three days to analyze real patient data from Froedtert Hospital and MCW, by applying machine learning and advanced statistical analysis to identify unique and novel findings and presented their final outcomes to a panel of judges. Mentors from participating institutions were available to the teams throughout the event. &nbsp;&nbsp;The topic of the event was “Obstructive Sleep Apnea and its Relationship with Cancer.” Obstructive sleep apnea (OSA) is a common sleeping disorder characterized by repeated breathing pauses during sleep that lead to fragmented sleep and decreased oxygen levels. OSA can affect at least one third of the adult population, if not more. Recent studies have suggested that several sleep disruptions and disorders represent significant risk factors for some forms of cancers. &nbsp;&nbsp;“These are major and very prevalent problems and disorders in the general population. As such, after a critical appraisal of the existing literature, and noticing several emergent relationships between different types of cancer and various sleep disorders, we proposed to explore if there was an actual connection between these disorders in a large, real-world healthcare dataset”, shared Octavian C. Ioachimescu, M.D., Ph.D., MBA, Professor of Medicine at MCW; CTSI Associate Director for Training and Education, medical director, Clinical Trials Office Integration at the CTSI of Southeast Wisconsin and Vice-Chair of Medicine for Clinical Research and Data Analytics. “The sky is the limit. Our talented students are here to help deciphering these relationships, and to create new knowledge.”&nbsp;“This Hackathon represented the strong culture of collaboration among our institutions. Collaboration is key to enhancing our ability to serve our patients and our communities, by allowing us to achieve together what we may not be able to achieve alone. Congratulations to all for this great achievement” shares Reza Shaker, M.D., Director of CTSI, Associate Provost, Senior Associate Dean and Division Chief for gastroenterology and hepatology at MCW.&nbsp;The opening and closing sessions were hosted on the MCW Milwaukee campus. Students were able to work at any of the four participating campuses over the course of the event. Each team submitted their programming code, followed by five-minute presentations, which were assessed by six volunteer judges representing the partner institutions and one external judge from Stanford University, i.e., Dr. Miranda Tan. &nbsp;&nbsp;The first-place team received a one-on-one mentoring session from a leader from one of the participating organizations. All winning teams were presented with trophies and different books on artificial intelligence at the closing event on April 28th. &nbsp;&nbsp;First place was awarded to Team 6:Xiaowei Dong, UWMAli Nemati, UWMYizhou Lu, UWMAravind Reddy Guda, UWMMentor: Brett Truelove, NMMentor: Spencer Huang, UWM&nbsp;Team 6 conducted a survival analysis to identify how OSA affects the likelihood of cancer mortality. Initial results with the data set provided demonstrated no significant difference regarding survival of patients with OSA compared to those without. Team members included biomedical Ph.D. students.&nbsp;Second place was awarded to Team 4: &nbsp;K M Sajjadul Islam, MarquetteJiawei Wu, MarquettePushyan Jhaveri, UWMVinaya Valsan, UWMMentor: Swapnil Tripathi, UWMMentor: Shengtong Han, Marquette&nbsp;Team 4 constructed a React application (a JavaScript-based user interface development library) that dissected the data and observed interactions between variables. The emphasis of their project was placed on the concept of building the app and the team showcased a live demonstration of the application during their presentation. Team members included students in the computer science/information science fields.&nbsp;&nbsp;Third place was awarded to Team 2: &nbsp;Prashansa Gharat, UWMAsha Dass, UWMJan Kretschmann, UWMOmar Abu-rmaileh, UWMMentor: Katia Mastropas, NMMentor: Huimin Zhao, UWM&nbsp;Team 2 concentrated on the types of cancers affected by OSA. The team was able to identify two types of cancers, lung and retroperitoneum/peritoneum, that have a significantly higher likelihood of presence after a patient is diagnosed with OSA. The team consisted of students in the computer science and information science fields. &nbsp;&nbsp;“These students are paving the pathway forward for new and novel research applications,” shared Jonathan Stark, Ed.D., Executive Director of the Northwestern Mutual Data Science Institute, “In my 20 years of working with students, I’m constantly amazed by their creativity and their enthusiasm.”&nbsp;The next Hack for Health event will build on the lessons learned and the solutions found during this inaugural event. The partner organizations hope to offer the event on a bi-annual basis.

Clinical and Translational Science Institute of Southeastern Wisconsin

Two students work together on their laptops as part of the "Hack for Health" event.

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Medical College of Wisconsin

Inaugural Hack for Health Explores the Relationship between Obstructive Sleep Apnea and Cancer

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Goal #6: Enhance training programs 

Christina Eckhardt, M.D., discusses the impact of receiving TL1-supported training and research at the Irving Institute.&nbsp;&nbsp;Because of this program, she found structure to research training in ways no other programs offered, was able to earn a master’s degree in patient-oriented research through the Mailman School of Public Health, and attended and presented at four international conferences where she connected with leaders in her field. She also received the support and dedicated time needed to work with her mentors, which led to five new publications in her field...&nbsp;&nbsp;Read the full article <a href="https://www.irvinginstitute.columbia.edu/news/cuimc-faculty-member-credits-tl1-program-their-success" target="_blank" rel="noopener noreferrer">here</a>.

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Engaging Community Stakeholders in Clinical Research Staff Training