Goal #7:  Training and career support programs for translational scientists

Date: Tuesday, April 2, 2024Time: 4 – 5 p.m. ETLocation: ZoomSpeaker: David C. Kaelber, M.D., Ph.D., M.P.H.&nbsp;Discover how to use an aggregated electronic health record platform with over 100 million patient records that Case Western Reserve University (CWRU) researchers, clinicians, trainees, and students have published over 100 peer-reviewed publications. &nbsp;&nbsp;Register for the event <a href="https://cwru.zoom.us/meeting/register/tJckcu6sqzkrGdFn8DH9h1dsfbhEPhyWqJu2#/registration" target="_blank" rel="noopener noreferrer">here</a>.&nbsp;More information about Dr. Kaelber can be found <a href="https://sites.google.com/a/case.edu/davidkaelber/home" target="_blank" rel="noopener noreferrer">here</a>.

Case Western Reserve University

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TriNetX – A New Tool for Scientific Discovery

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Goal #1: Advance clinical and translational science

Stanford University’s School of Medicine (SoM) Program on Research Rigor &amp; Reproducibility (<a href="https://med.stanford.edu/sporr" target="_blank" rel="noopener noreferrer">SPORR</a>) hosted its second school-wide Rigor &amp; Reproducibility Colloquium: Conversations on How to Future-Proof our Science on January 29, 2024. On February 1, SPORR’s CTSA institutional survey results on rigor and reproducibility were published in the Journal of Clinical and Translational Science.&nbsp;The colloquium featured introductory remarks from SoM Senior Associate Dean for Research <a href="https://profiles.stanford.edu/ruth-ohara" target="_blank" rel="noopener noreferrer">Ruth O’Hara, Ph.D.</a> and SPORR Director <a href="https://med.stanford.edu/sporr/about/facultyandstaff/steven-goodman.html" target="_blank" rel="noopener noreferrer">Steven Goodman, M.D., M.H.S., Ph.D.</a> Dr. Goodman explained that SPORR was less focused on research misconduct than on research “dysconduct”—practices or procedures that weaken either the reliability of research findings or confidence in them. These were followed by plenary talks from <a href="https://obgyn.duke.edu/profile/geeta-krishna-swamy" target="_blank" rel="noopener noreferrer">Geeta K. Swamy, M.D.</a> (Associate Vice President for Research, and Vice Dean for Scientific Integrity at Duke University) who spoke of the changes implemented at Duke University to promote a culture of research integrity, which led to a network of research quality representatives being embedded in every school department to help their faculty. <a href="https://dbmi.hms.harvard.edu/people/alexa-mccray" target="_blank" rel="noopener noreferrer">Alexa T. McCray, Ph.D.</a>, Professor of Medicine, Harvard Medical School, the first head of Clinicaltrials.gov and the National Library of Medicine intramural research branch, described a two-year self-study she co-led on Harvard’s rigor and reproducibility (and responsibility—R3) practices that has led to a <a href="https://ari.hms.harvard.edu/hms-r3" target="_blank" rel="noopener noreferrer">range of initiatives there</a>.&nbsp;The event also featured a roundtable with SoM faculty and staff on their recommended approaches to enhancing research rigor and reproducibility at Stanford. SPORR Director Dr. Goodman then described current and future <a href="https://med.stanford.edu/sporr.html" target="_blank" rel="noopener noreferrer">SPORR activities</a>, which included several new courses, an upcoming school-wide data management survey, and the establishment under Dr. O’Hara of a SoM Task Force on Research Practice and Culture. Finally, SPORR is working with SoM Vice Dean Linda Boxer on a new optional format for a SoM CV that can make faculty use of optimal research practices more visible in the appointment and promotions process.&nbsp;SPORR gave out two monetary Rigor and Reproducibility—RaRe—Researcher Awards to early career researchers. One was to <a href="https://profiles.stanford.edu/jan-niklas-hansen" target="_blank" rel="noopener noreferrer">Jan Niklas Hansen, Ph.D.</a>, post-doc in the Lundberg lab, for creation of free software that allows complex image analysis of moving organisms. The second was to <a href="https://profiles.stanford.edu/Kif%20Liakath-Ali" target="_blank" rel="noopener noreferrer">Kif Liakath-Ali, Ph.D., M.Sc.,</a> post-doc in the Sudhöf lab, for using rigorous experimental designs that debunked a previously accepted finding on neuronal plasticity, with the subsequent publication of a “negative” result that stimulated confirmation by others and had significant consequences for the field.&nbsp;According to Dr. Goodman, “Stanford is home to some of the world’s most brilliant and creative biomedical scientists. SPORR is a community effort to harness that creativity—learning from each other—so our scientific ecosystem maximally benefits every SoM investigator. We should lead the world not only through our scientific output, but in how we do our science.”&nbsp;The event recording can be seen <a href="https://med.stanford.edu/sporr/education/colloquium.html" target="_blank" rel="noopener noreferrer">here</a>.&nbsp;Just days after the colloquium, the Journal of Clinical and Translational Science published the results of an institutional survey conducted by Dr. Steve Goodman, <a href="https://profiles.stanford.edu/232543?tab=bio" target="_blank" rel="noopener noreferrer">Mario Malicki, Ph.D., M.A., M.D.</a>, and <a href="https://metrics.stanford.edu/people/cathrine-axfors" target="_blank" rel="noopener noreferrer">Cathrine Axfors, Ph.D.</a> assessing the rigor and reproducibility activities of institutions funded by the National Center for Advancing Translational Sciences (NCATS). Read the article <a href="https://www.cambridge.org/core/journals/journal-of-clinical-and-translational-science/article/research-rigor-and-reproducibility-in-research-education-a-ctsa-institutional-survey/3B8FA1E860C49DDAF7B5CD1D3E2169AF" target="_blank" rel="noopener noreferrer">here</a>.&nbsp;About SPORR&nbsp;SPORR is an initiative started in 2020 to train and assist Stanford School of Medicine investigators to optimize the rigor and reproducibility (“R&amp;R”) of their research. SPORR is directed by Dr. Steven Goodman and is part of Spectrum, Stanford’s Center for Clinical and Translational Research and Education, directed by Dr. Ruth O’Hara, Senior Associate Dean of Research, and supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR003142.

Stanford

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Stanford University

Stanford’s SPORR Holds Rigor & Reproducibility Colloquium, Publishes CTSA-wide Survey Results 

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Goal #2: Promote partnerships and collaborations

Patrick Flume, M.D., the Powers-Huggins Endowed Chair for Cystic Fibrosis at Medical University of Southern California (MUSC), was honored with the prestigious 2024 Impact Award by the Cystic Fibrosis Foundation at its second annual Breath of Life Celebration in Charleston, South Carolina. More than 300 leaders and colleagues gathered at the annual gala event on Feb. 23 to celebrate Flume’s achievements. &nbsp;&nbsp;Flume, an internationally recognized expert and leader in the field of cystic fibrosis (CF), received the award for his unwavering dedication to improving the lives of individuals with cystic fibrosis and advancing research in the field. &nbsp;&nbsp;“I am deeply appreciative of and profoundly humbled by this acknowledgment,” said Flume. “I am grateful for the opportunities afforded to me yet acutely aware that my success is bolstered by a team of exceptional individuals who enhance and elevate my efforts daily. The underlying lesson here is the importance of assembling a capable team and entrusting them to excel at their roles...”&nbsp;Read the full article <a href="https://web.musc.edu/about/news-center/2024/03/18/flume-impact-award" target="_blank" rel="noopener noreferrer">here</a>.&nbsp;

Medical University of South Carolina

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Renowned Cystic Fibrosis Expert Honored with 2024 Impact Award   

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TriNetX – A New Tool for Scientific Discovery