Goal #3: Address health disparities 

A recent study with researchers from Penn State CTSI aims to explore the effects of PCOS and metabolic syndrome in Hispanic/Latino females. PCOS is a complex, multifaceted endocrine disorder and though it is associated with inflammation and metabolic syndrome, moderating effects of inflammation haven’t been studied in this population, who have a higher metabolic burden.&nbsp;Read the full journal article <a href="https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae426/7695535?redirectedFrom=fulltext" target="_blank" rel="noopener noreferrer">here</a>.

Penn State Clinical and Translational Science Institute

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Pennsylvania State University

Polycystic Ovary Syndrome, Metabolic Syndrome, and Inflammation in the Hispanic Community Health Study

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Goal #1: Advance clinical and translational science

More than four years after the onset of the COVID-19 pandemic, researchers are still shedding light on the consequences of its transmission—one focus being on its relation to pregnancy and fetal health.&nbsp;Andrea Kovacs, M.D., a professor in Pediatrics and Pathology as well as Chief of Pediatric Infectious Diseases at the Los Angeles General Medical Center and Keck School of Medicine of the University of Southern California (USC), has extensive experience in clinical research on pathogenesis and transmission of diseases like human immunodeficiency virus (HIV), hepatitis C virus (HCV) and human cytomegalovirus (CMV). However, the HIV program she began at USC was halted in 2020 when she shifted her focus to COVID-19…&nbsp;Read the full article <a href="https://sc-ctsi.org/news/usc-investigator-makes-new-discoveries-on-the-transmission-of-covid-19-in-pregnant-patients" target="_blank" rel="noopener noreferrer">here</a>.

Southern California Clinical and Translational Science Institute

"Instead of crossing the placenta, this could be an ascending infection similar to STDs and other infections that transmit to babies...up to now, people just assumed that it came from exposure in-utero to the mother."- Andrea Kovacs, MD

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University of Southern California

University of Southern California Investigator Makes New Discoveries on the Transmission of COVID-19 in Pregnant Patients

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Goal #6: Enhance training programs 

Despite the long-standing calls for increased levels of interdisciplinary research as a way to address society’s grand challenges, most science is still disciplinary. To understand the slow rate of convergence to more interdisciplinary research, we examine 154,021 researchers who received a Ph.D. in a biomedical field between 1970 and 2013, measuring the interdisciplinarity of their articles using the disciplinary composition of references. We provide a range of evidence that interdisciplinary research is impactful, but that those who conduct it face early career impediments. The researchers who are initially the most interdisciplinary tend to stop publishing earlier in their careers—it takes about 8 y for half of the researchers in the top percentile in terms of initial interdisciplinarity to stop publishing, compared to more than 20 y for moderately interdisciplinary researchers (10th to 75th percentiles). Moreover, perhaps in response to career challenges, initially interdisciplinary researchers on average decrease their interdisciplinarity over time. These forces reduce the stock of interdisciplinary researchers who can train future cohorts. Indeed, new graduates tend to be less interdisciplinary than the stock of active researchers. We show that interdisciplinarity does increase over time despite these dampening forces because initially disciplinary researchers become more interdisciplinary as their careers progress…&nbsp;Read the full journal article <a href="https://www.pnas.org/doi/10.1073/pnas.2402646121" target="_blank" rel="noopener noreferrer">here</a>.

The Ohio State University Center for Clinical and Translational Science

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Ohio State University

Slow Convergence: Career Impediments to Interdisciplinary Biomedical Research

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Polycystic Ovary Syndrome, Metabolic Syndrome, and Inflammation in the Hispanic Community Health Study