Goal #1: Advance clinical and translational science

NCATS is seeking 4UL1/UM1 PIs to serve on the Steering Committee (SC) for the&nbsp;next 2-3 years (2025 – 2028).&nbsp; If you would like to self-nominate or suggest a fellow PI, please submit the PI name, institution, and brief explanation. The eligibility criteria for SC appointments:&nbsp; &nbsp;<ul><li>A PI must be officially named in the Notice&nbsp;of Grant Award of an active CTSA Program&nbsp;hub.?</li><li>The PI’s hub award must have at least 3&nbsp;years remaining during the project&nbsp;period.&nbsp;?</li><li>The PI has not served on the SC since&nbsp;December&nbsp;2018?</li></ul>&nbsp;Please email&nbsp;Stephanie Ezequiel (<a href="mailto:Stephanie.Ezequiel@nih.gov" target="_blank" rel="noopener noreferrer">Stephanie.Ezequiel@nih.gov</a>)&nbsp;with any questions.&nbsp; Nominations are due by Wednesday, October 16th, 2024.&nbsp;Submit your nominations <a href="https://forms.office.com/Pages/ResponsePage.aspx?id=eHW3FHOX1UKFByUcotwrBmFG7mB4bKVHtunoBigfeD1UN05NRFowNlk1WEs5VFozTzZRQzZXUzdPUi4u&amp;wdLOR=c82DC0A42-8AE3-4E98-A236-D0AEF01404B8" target="_blank" rel="noopener noreferrer">here</a>.

National Institutes of Health (NIH)

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National Center for Advancing Translational Sciences

NCATS is Seeking Nominations for New CTSA Program Steering Committee Members!

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Goal #5: Provide a national resource for public health needs

Three reports were recently made available to inform researchers on how PCORnet can be used for patient-centered clinical effectiveness research on specific populations: Maternal Morbidity and Mortality, Intellectual and Developmental Disabilities, and Telehealth utilization. &nbsp; PCORnet is a large, distributed “network of networks” funded by the Patient-Centered Outcomes Research Institute (PCORI) to improve the nation’s capacity to efficiently conduct definitive health research, particularly patient-centered comparative clinical effectiveness research.&nbsp; At the time of these query reports, PCORnet included 63 data contributing Clinical Research Networks (CRN) sites representing more than 13,000 clinical sites connected to more than 34 million unique patients receiving care across the U.S. each year, including care delivered at large academic health systems, hospitals, federally qualified health centers, and community clinics…&nbsp;Read the full article <a href="https://ctsi.wakehealth.edu/announcements/2024/07/pcornet-populations-descriptive-reports" target="_blank" rel="noopener noreferrer">here</a>.

Wake Forest Clinical and Translational Science Institute

PCORnet: The National Patient-Centered Clinical Research Network

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Wake Forest University

PCORnet Populations Descriptive Reports

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Goal #3: Address health disparities 

Despite the prevalence and toll of late-onset Alzheimer’s disease—the most common type, which begins after age 65—causes of the disease remain only partly understood. Is it genes? Lifestyle? Environment?&nbsp;Current scientific understanding says it’s a combination of these factors, but we still don’t understand exactly how they interact to affect someone’s risk of developing the disease.&nbsp;Research indicates that more than 80 genetic variants might have a role in someone’s susceptibility to late onset-Alzheimer’s disease (LOAD), and twin studies suggest that between 60-80% of cases are heritable. But not everyone who has LOAD risk genes develops the condition, and some people without risk genes do. &nbsp;Further complicating matters is that risk genes seem to have different effects across racial and ethnic groups, and environmental exposures can amplify or lessen the role of risk genes…&nbsp;Read the full article <a href="https://www.ccts.uky.edu/index.php/news/dream-scholar-explores-gene-and-environment-interactions-underlying-alzheimers-disease" target="_blank" rel="noopener noreferrer">here</a>.

Kentucky Center for Clinical and Translational Science

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University of Kentucky

DREAM Scholar Explores Gene and Environment Interactions Underlying Alzheimer’s Disease

CTSA CCOS

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NCATS is Seeking Nominations for New CTSA Program Steering Committee Members!