Goal #1: Advance clinical and translational science

The Enhancing Quality in the Translational Research Workforce Conference (EQuaTR) — held April 10, 2024 on the Northwestern Medicine campus — created the type of interactive platform that are a hallmark of collaborative events co-hosted by the Northwestern University Clinical and Translational Sciences (NUCATS) Institute, the Institute for Translational Medicine (ITM), and the University of Illinois at Chicago Center for Clinical and Translational Science (CCTS).&nbsp;Open to professionals in clinical and translational research, the conference is led by Northwestern University Feinberg School of Medicine’s Sharon Rosenberg, M.D., in collaboration with an advisory board tasked with developing an annual conference agenda that aims to engage the larger medical community while simultaneously providing breakout sessions to connect in smaller settings.&nbsp;“EQuaTR allows the Chicagoland Clinical and Translational Science Award hubs and research community to come together to join in learning and networking. The speakers and breadth of knowledge shared was outstanding and I especially enjoyed seeing attendees make new connections within the Chicagoland research community,” said Dr. Rosenberg, a professor of Pulmonary and Critical Care in the Department of Medicine who has been a part of the NUCATS Institute for nearly a decade...&nbsp;Read the full article <a href="https://www.nucats.northwestern.edu/about/news/2024/equatr-2024.html" target="_blank" rel="noopener noreferrer">here</a>.

Northwestern University at Chicago

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Northwestern University At Chicago

Enhancing Quality in the Translational Research Workforce Conference Explores Clinical Research in Age of Artificial Intelligence 

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The CCOS Communications Team interviewed researchers at the <a href="https://ccos-cc.ctsa.io/groups/program-meetings/2023/fall-meeting?view=meeting-details" target="_blank" rel="noopener noreferrer">2023 CTSA Fall Program Annual Meeting</a> poster session in November as part of a series to feature ongoing projects across the CTSA hubs. In this article, we’re featuring Dr. Ryan Notti, KL2/K12 at Rockefeller University, who presented his work on the <a href="https://ccos-cc.ctsa.io/groups/program-meetings/2023/fall-meeting?view=poster-gallery&amp;poster=192">resting state of human T-cell receptors from the perspective of AI shortcomings and empirical insights</a>.&nbsp;&nbsp;Research Question&nbsp;T-cell receptors (TCR), central to the ligand-dependent activation of T-cells, are vital in orchestrating adaptive and innate immune responses. Despite their important role, there are still major gaps in knowledge regarding the structure and function of these receptors in humans. As such, Dr. Notti and his team used cryogenic electron microscopy and in silico modeling to better understand structures of unliganded human TCR in a native-like lipid bilayer.&nbsp;&nbsp;Research Plan&nbsp;Dr. Notti and his team used cryogenic electron microscopy to reveal three related “closed and compacted” TCR conformations that are distinct from previously reported “extended” structures of TCR in detergent and predicted by AI. These findings underscore the importance of studying the TCR in native-like environments to correctly characterize the resting state of the receptor. The team also modeled their newly discovered TCR conformations in silico and distinguished which could accept binding from ligands, and which could not. They demonstrated that TCR-intrinsic conformational change is necessary for TCR activation.&nbsp;&nbsp;&nbsp;Next Steps&nbsp;The new TCR resting conformation reveals newly discovered biology of the receptor and has implications for the design of new T-cell targeting therapeutics. The findings open numerous doors regarding immunoreceptor engineering, allowing for structure-informed studies of patient TCR genetics and response to cancer immunotherapy.&nbsp;&nbsp;Reflection with the Researcher: What do you want the general public to know about the work you’re presenting here tonight?&nbsp;&nbsp;&nbsp;Dr. Notti stated that “Our ability to take pictures of molecules has drastically improved over the last decade, and these advancements will lead to better therapies for our patients in the future.”&nbsp;&nbsp; &nbsp;

Rockefeller University

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2023 CTSA Fall Program Annual Meeting Poster Spotlight: Ryan Notti, M.D., Ph.D.

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Goal #2: Promote partnerships and collaborations

Date: Wednesday, May 7, 2024Time: 6:00 p.m. - 7:00 p.m. ET&nbsp;The Tufts CTSI is holding their 3rd Annual Dissemination of Research Results Open House Zoom event on Tuesday, May 7, from 6:00 p.m. - 7:00 p.m. ET.&nbsp;The event is free and open to the public, but registration is required. We are excited to have Erin Meier, M.D., from Northeastern University and Gaurav Gulati, M.D., from Tufts Medical Center scheduled to present the results of their studies. This event is an opportunity for study participants to learn about the results of the study in which they participated. It is also an opportunity for the general public to learn more about research happening at Tufts Medical Center and Northeastern University. Each 15-minute presentation will be followed by a Q&amp;A session with the researchers.&nbsp;Learn more and register for the event <a href="https://www.tuftsctsi.org/events/3nd-annual-dissemination-of-research-results-open-house/" target="_blank" rel="noopener noreferrer">here</a>.

Tufts University Boston

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Tufts CTSI 3rd Annual Dissemination of Research Results Open House

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Enhancing Quality in the Translational Research Workforce Conference Explores Clinical Research in Age of Artificial Intelligence