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May 15, 2025

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Advancing Sepsis Research: A Wake Forest CTSI Pilot Program Success Story

Ashish K. Khanna, M.D., M.S., FASA, FCCM a Professor of Anesthesiology in the section on Critical Care Medicine at Wake Forest University School of Medicine, received the 2024-2025 Science of Translation Pilot Recipients award for his project ‘Precision-Based Renin Assessment in Septic Shock Outcomes.’ As a senior investigator, he applied to the Wake Forest Clinical and Translational Science Institute (CTSI) Pilot Program to obtain preliminary data for future grant applications. The program's focus on collaborative research networks matched his research goals, providing an excellent platform for scientific advancements.

Dr. Khanna’s current project focuses on understanding the dysfunction within the renin-angiotensin-aldosterone system (RAAS) in septic shock. Conducted as a prospective study, the research involves enrolling adult patients with septic shock across multiple sites, including the main campus ER and ICU in Winston-Salem, North Carolina as well as facilities at High Point and Charlotte. The goal is to identify a set of RAAS biomarkers that can most precisely predict patient outcomes and potentially guide early therapeutic interventions, ultimately improving care for those suffering from septic shock…

 

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